Prospective microRNA Profiles

MicroRNA¹	Alzheimer Disease Affected Tissue					Aging Model	Reference
MicroRNA¹	Cortex	Hippocampus	Cerebellum	CSF	PBMC	Aging Model	Reference
Down-Regulated
let-7i	↓					↓	[96,169]
miR-9	↓	↓	↓				[99, 96]
miR-15	↓			↓			[99, 96]
miR-146b	↓	↓	↓	↓			[99]
miR-181c	↓			↓			[99, 96]
miR-210	↓	↓					[99, 96]
miR-338	↓			↓			[99, 96]
miR-451				↓		↓	[99, 169]
Up-Regulated
let-7f				↑	↑	↑	[99, 39, 181]
miR-30d				↑		↑	[99, 169]
miR-34a	↑	↑	↑		↑	↑	[39, 99, 169, 170]
miR-125b	↑	↑	↑				[99, 98]
miR-197	↑			↑			[99, 96]
miR-200a	↑				↑		[99, 39]
miR-371				↑	↑		[99, 39]
miR-517				↑	↑	↑	[99, 39]
miR-520h	↑				↑		[96, 39]

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Name	Reason	Article
hsa-miR-30d-5p	It's the most up regulated	A blood based 12-miRNA signature of Alzheimer disease patients
hsa-miR-144-5p	It's the most down regulated	A blood based 12-miRNA signature of Alzheimer disease patients
hsa-let7f-5p	it's upregulated, and it shows up a lot	A blood based 12-miRNA signature of Alzheimer disease patients
has-miR-125b	up regulated in response to oxidative damage	Studying micro RNA function and dysfunction in Alzheimer’s disease
has-miR-146a	greatest up regulation as part of neuroinflamation	Studying micro RNA function and dysfunction in Alzheimer’s disease
has-miR-181c	down regulated by Aβ-42	Target gene repression mediated by miRNAs miR-181c and miR-9 both of which are down-regulated by amyloid-β
has-miR-9	down regulated by Aβ-42	Target gene repression mediated by miRNAs miR-181c and miR-9 both of which are down-regulated by amyloid-β