Questions from Last Time:
1. What does the interaction time between a T Cell and an APC look like for T Cells that bind the antigen the cell is presenting as opposed to those that do not bind?
1a. How long does it take the T Cell to kill the APC if it is a match?
2. What kinds of chemicals go back and forth between the T Cell and the APC during this process and how are they released (transcriptional response/some other signaling cascade)?
3. What kinds of chemicals are released by the Tregs to suppress Teffs?
- IL10
- TGFβ
-...
4. How can we modify MHC (or other APC surface protein) to release the chemicals normally released by Tregs when a Teff successfully binds MHC?
Other New, Relevant Information: