Questions from Last Time:
1. What does the interaction time between a T Cell and an APC look like for T Cells that bind the antigen the cell is presenting as opposed to those that do not bind?
1a. How long does it take the T Cell to kill the APC if it is a match?
2. What kinds of chemicals go back and forth between the T Cell and the APC during this process and how are they released (transcriptional response/some other signaling cascade)?
- Cytotoxic T Cells Release perforin, granzymes and granulysin. Perforin makes holes in cell membrane through which the other proteins can enter, granzymes trigger caspase cascade resulting in apoptosis
3. What kinds of chemicals are released by the Tregs to suppress Teffs?
- IL10
- TGFβ
-...
4. How can we modify MHC (or other APC surface protein) to release the chemicals normally released by Tregs when a Teff successfully binds MHC?
Other New, Relevant Information: