Add to presentation:
- status
- transfection data
- plasmid/part information
- cell culture done and planning to do
- miRNA
- add logic circuit diagram to miRNA classifier circuit
- remove cancer classifier circuit
- pictures - who we are slide
- progression of the disease: where does it start - where does it end up
- who we are before why are we working on alzheimer's
Presenting:
- not overselling - set the right expectations
- not underselling
- concise and to the point
- intro statistic slide is not engaging
- put in diagram showing pathways of the disease to emphasize the complexity of the disease
- mentioning the process of generating the project - brainstorming
- iap activities
- many students in igem stay and work on independent projects
- characteristics of alzheimer's: remove the bullets and enhance the graphics
- cite images
- more fluid animation for BCell Receptor group
- make a diagram like the cancer classifier circuit for the miRNA
- miRNA explanation should be smoother
Rationale: why are we using synthetic biology to treat this problem:
- Alzheimer's disease has a set of very well defined characteristics that we can use as inputs for our processing circuit
- we are beginning to understand the molecular basis of the disease
- emphasize the complexity of the disease
Treatment:
- show cleavage of beta-amyloid oligomers on the diagram of beta-amyloid formation
- detection module not membrane bound (also not like tango system) - transcription factor - treatment REDO DIAGRAM
Conclusion:
this is where we are and this is where we are going
- eg. we are beginning to manipulate mammalian cells and this is what we have (microscopy picture)