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Upon detection of beta-amyloid plaques (by receptor protein binding or by miRNA sensing) a transcription factor is cleaved from the receptor protein (LilrB2 or PirB) to then promote expression of a miRNA as well as BACE2. This miRNA, in turn, down-regulates BACE1.
Experiments
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Experiments
Seeding 24-well Plate......Transfection......FACS
| Experiment |
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Demonstrate effectiveness of miRNA in down-regulating BACE1 |
Demonstrate inducible upregulation of BACE2-YFP |
Purchases
| Item | Link |
|---|
Purchases
| Item | Link | Purchased? |
|---|---|---|
| BACE2 | http://dnasu.org/DNASU/GetCloneDetail.do?cloneid=4116676140 | |
Appendix
data sets
| BACE1 | http://dnasu.org/DNASU/GetCloneDetail.do?cloneid=78236 |
| Bace2 activity assay | https://www. |
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| products/product.asp?id=57836 | |
| Bace1 activity assay | http:// |
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cloneid=78236 (human BACE1; pricing given only to registered customers)