| Overview |
|---|
Relying on miRNAs, we can measure the expression of a variety of genes associated with Alzheimer's. The implementation of such a system is eased by research into Alzheimer specific miRNA signatures and the recent publication of a circuit for taking multiple miRNA inputs to mediate a desired output. Specific output relevant to our system is under development by the treatment module, so this module will use a generic output and focus on attempting to accurately identifying the presence of factors associated with Alzheimer's, preferably in the early stage before symptoms set in. |
...
- Detection of miRNA associated with factors.
- Construction of profile matching circuit.
- Reinforcing logical soundness and robustness of circuit.
...
Workflow
Circuit Diagrams
Complete Circuit Schematic
| miR-30d | miR-7f | miR-125b | miR-146a | L7ae | miR-144 | miR-181c | rtTA |
|---|---|---|---|---|---|---|---|
| 0 | 0 | 0 | 0 | TRUE | 0 | 0 | FALSE |
| 1 | 0 | 1 | 1 | TRUE | 0 | 0 | FALSE |
| 1 | 1 | 1 | 1 | FALSE | 1 | 0 | FALSE |
| 1 | 1 | 1 | 1 | FALSE | 1 | 1 | FALSE |
| 1 | 1 | 1 | 1 | FALSE | 0 | 1 | FALSE |
| 1 | 1 | 1 | 1 | FALSE | 0 | 0 | TRUE |