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Expression Levels in Cell Lines

PresursorMatureRegulationmiRNA SequencemiRNA Target Sequencettest rawparticle
hsa-mir-144hsa-miR-144-5pDownGGAUAUCAUCAUAUACUGUAAGCUUACAGUAUAUGAUGAUAUCC2.91772E-08A blood based 12-miRNA signature of Alzheimer disease patients
hsa-mir-30dhsa-miR-30d-5pUpUGUAAACAUCCCCGACUGGAAGCUUCCAGUCGGGGAUGUUUACA8.17041E-14A blood based 12-miRNA signature of Alzheimer disease patients
hsa-let-7f-1

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http://www.ncbi.nlm.nih.gov/pubmed/24858274

 

MicroRNA1Alzheimer Disease Affected TissueAging ModelReference
CortexHippocampusCerebellumCSFPBMC
Down-Regulated 
let-7i↓    ↓[96,169]
miR-9↓↓↓   [99, 96]
miR-15↓  ↓  [99, 96]
miR-146b↓↓↓↓  [99]
miR-181c↓  ↓  [99, 96]
miR-210↓↓    [99, 96]
miR-338↓  ↓  [99, 96]
miR-451   ↓ ↓[99, 169]
Up-Regulated 
let-7f   ↑↑↑[99, 39, 181]
miR-30d   ↑ ↑[99, 169]
miR-34a↑↑↑ ↑↑[39, 99, 169, 170]
miR-125b↑↑↑   [99, 98]
miR-197↑  ↑  [99, 96]
miR-200a↑   ↑ [99, 39]
miR-371   ↑↑ [99, 39]
miR-517   ↑↑↑[99, 39]
miR-520h↑   ↑ [96, 39]

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2705849/

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2705849/

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http://genomebiology.com/2013/14/7/R78

 

 

Order?R
-34aU
-146aU
let-7fU
-9D
-146aD
-181cD
-106a/bD
-107D
-29a/bD
  
up regulated in response to oxidative damagehasgreatest up regulation as part of neuroinflamationhasmiRTarget gene repression mediated by miRNAs and miR-9 both of which are down-regulated by amyloid-βdown regulated by Aβ-42

Up-Regulated

Down-Regulated

brain-miR-112

hsa-miR-107

brain-miR-161

hsa-miR-103a-3p

hsa-miR-26a-5p

hsa-miR1-532-5p

hsa-miR-5010-3p

hsa-miR-26b-5p

hsa-miR-1285-5phsa-let-7f-5p

hsa-miR-151a-3p

 

hsa-let-7d-3p

 
NameReasonArticle
UpUGAGGUAGUAGAUUGUAUAGUUAACUAUACAAUCUACUACCUCA1.39318E-07hsa-miR-30d-5pIt's the most up regulatedA blood based 12-miRNA signature of Alzheimer disease patients
hsa-miRlet-1447f-5pIt's the most down regulatedA blood based 12-miRNA signature of Alzheimer disease patients
hsa-let-7f-5pit's upregulated, and it shows up a lotA blood based 12-miRNA signature of Alzheimer disease patients
23.90488E-07
hsa-mir-125b-1hsa-miR-125b-5pUpUCCCUGAGACCCUAACUUGUGAUCACAAGUUAGGGUCUCAGGGA0.318894647has-miR-125bStudying micro RNA function and dysfunction in Alzheimer’s disease
hsa-mir-125b-20.313925311
hsa-mir-146ahsa-miR-146a-5pUpUGAGAACUGAAUUCCAUGGGUUAACCCAUGGAAUUCAGUUCUCA0.675302536Studying micro RNA function and dysfunction in Alzheimer’s disease
hsa-mir-181cdown regulated by Aβ-42hsa-miR-181chas-miR-9-5pDownAACAUUCAACCUGUCGGUGAGUACUCACCGACAGGUUGAAUGUU0.884865736Target gene repression mediated by miRNAs miR-181c and miR-9 both of which are down-regulated by amyloid-β