Overview:
The plaques found in the brain of a patient with Alzheimer's disease comprise beta-amyloid protein oligomers, which are responsible for the degenerative symptoms of the condition. In order to diagnose and/or treat Alzheimer's disease, we must first be able to detect the presence of these beta-amyloid oligomers. One of the possible methods of detection is the use of beta-amyloid oligomer-specific transmembrane receptors.
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- Finish making primers for LilrB2 and PirB fusion proteins.
- Possibly make primers to amplify LilrB2 and PirB stocks.
- Start GoldenGate reactions for LilrB2 and PirB (followed by gibsons; in the Experiment list)
Experiments:
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Making beta-oligomers and testing the selectivity of the receptors to beta-amyloid oligomers vs beta-amyloid monomers
Progress:
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To Do: