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Phagocytic Clearance in Neurodegeneration (Phagocytic clearance in Neurodegeneration (and AD).pdf)

Variant of TREM2 Associated with the Risk of Alzheimer’s Disease (TREM2 variant and WBC as AD risk factor.pdf)

N-APP binds DR6 to cause axon pruning and neuron death via distinct caspases (DR6 death receptor and N-APP (beta-amyloid cousin) binding.pdf)


6/11/14


Further reading of "Phagocytic Clearance in Neurodegeneration" revealed that AB (which form?) causes an inflammatory response in microglia that is responsible for neurodegeneration, while upregulating anti-inflammatory cytokines could help increase phagocytic activity and reduce neurodegeneration. Could that be an added/alternate approach? How would we test if it is working?

Image Added

Looking into:

TGF-β1 promotes microglial amyloid-β clearance and reduces plaque burden in transgenic mice TGF-beta1 promotes microglial AB clearance.pdf

Microglia Lacking E Prostanoid Receptor Subtype 2 Have Enhanced Aβ Phagocytosis yet Lack Aβ-Activated Neurotoxicity Microglia Lacking E Prostanoid Receptor Subtype 2 have enhanced AB phagocytosis.pdf

 

Also need to look into:

 

Do macrophages actually "evolve" into microglia once in the brain or are they different?

Microglia in the adult brain arise from Ly-6ChiCCR2+ monocytes only under defined host conditions microglia from monocytes.pdf